Figure 4.

mahe genetically interacts with members of the Notch signaling pathway. (A) Adult eye with normal morphology. (B and C) N⁵⁴¹⁹ and dx¹⁵² alone have no effect on eye size. (D) Overexpression of mahe with ey-GAL4 results in marked reduction in eye size in 100% of adults examined (n = 532). (E) Single copy of N⁵⁴¹⁹, a null allele of Notch in combination with overexpressed mahe, results in a massive reduction in eye size in 100% of adult eyes examined (n = 12). (F) mahe overexpression in combination with dx¹⁵² (a null allele of deltex) results in mild rescue of eye size in 32% of adult eyes examined (n = 29). (G) Adult wing with C96-GAL4 driver alone shows normal morphology. (H) Expression of mahe with C96-GAL4 does not affect wing morphology. (I) Overexpression of Dx alone with C96-GAL4 results in mild irregularities of bristle pattern (n = 80). (J) Coexpression of Dx and Mahe results in wing nicking at the margin in 31% of wings examined (n = 113) (arrow). Bars in G–J, 100 µm.