. 2015 Sep 9;201(3):1263–1274. doi: 10.1534/genetics.115.181099

Table 1. Human cDNAs that complement essential yeast deletion mutants.

Yeast systematic name	Yeast standard name	Human Entrez Gene ID	Human standard name	Yeast gene brief description^d
YBL020W	RFT1^a	29927	SEC61A1	Membrane protein required for translocation of Man5GlcNac2-PP-Dol
YBR002C	RER2	79947	DHDDS	Cis-prenyltransferase involved in dolichol synthesis
YBR029C	CDS1	8760	CDS2	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase)
YBR109C	CMD1^b	801; 805; 808	CALM1; CALM2; CALM3	Calmodulin
YBR160W	CDC28^b	983; 1017	CDK1; CDK2	Cyclin-dependent kinase (CDK) catalytic subunit
YBR252W	DUT1	1854	DUT	Deoxyuridine triphosphate diphosphatase (dUTPase)
YCR012W	PGK1^b	5230; 5232	PGK1^c; PGK2	3-Phosphoglycerate kinase
YDL045C	FAD1^b	80308	FLAD1^c	Flavin adenine dinucleotide (FAD) synthetase
YDL064W	UBC9^b	7329	UBE2I	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway
YDL120W	YFH1	2395	FXN	Mitochondrial matrix iron chaperone
YDL147W	RPN5^b	5718	PSMD12^c	Subunit of the CSN and 26S proteasome lid complexes
YDL164C	CDC9^b	3978	LIG1^c	DNA ligase found in the nucleus and mitochondria
YDL205C	HEM3	3145	HMBS	Porphobilinogen deaminase
YDR050C	TPI1^b	7167	TPI1	Triose phosphate isomerase, abundant glycolytic enzyme
YDR086C	SSS1	23480	SEC61G	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p)
YDR208W	MSS4^b	8394; 8395	PIP5K1A; PIP5K1B^c	Phosphatidylinositol-4-phosphate 5-kinase
YDR236C	FMN1	55312	RFK	Riboflavin kinase, produces riboflavin monophosphate (FMN)
YDR404C	RPB7^b	5436	POLR2G	RNA polymerase II subunit B16
YDR454C	GUK1	2987	GUK1	Guanylate kinase
YDR510W	SMT3^b	7341	SUMO1^c	Ubiquitin-like protein of the SUMO family
YEL026W	SNU13^b	4809	NHP2L1	RNA binding protein
YEL058W	PCM1	5238	PGM3	Essential N-acetylglucosamine-phosphate mutase
YER094C	PUP3^b	5691	PSMB3	Beta 3 subunit of the 20S proteasome
YER112W	LSM4	25804	LSM4	Lsm (Like Sm) protein
YER133W	GLC7^b	5499; 5501	PPP1CA; PPP1CC	Type 1 serine/threonine protein phosphatase catalytic subunit
YER136W	GDI1	2665	GDI2	GDP dissociation inhibitor
YFL017C	GNA1^b	64841	GNPNAT1^c	Glucosamine-6-phosphate acetyltransferase
YGL001C	ERG26	50814	NSDHL	C-3 sterol dehydrogenase
YGL030W	RPL30^b	6156	RPL30	Ribosomal 60S subunit protein L30
YGL048C	RPT6	5705	PSMC5	ATPase of the 19S regulatory particle of the 26S proteasome
YGR024C	THG1	54974	THG1L	tRNAHis guanylyltransferase
YGR075C	PRP38	55119	PRPF38B	Unique component of the U4/U6.U5 tri-snRNP particle
YGR175C	ERG1	6713	SQLE	Squalene epoxidase
YGR185C	TYS1	8565	YARS	Cytoplasmic tyrosyl-tRNA synthetase
YGR277C	CAB4	80347	COASY	Subunit of the CoA-synthesizing protein complex (CoA-SPC)
YGR280C	PXR1	54984	PINX1	Essential protein involved in rRNA and snoRNA maturation
YIL083C	CAB2	79717	PPCS	Subunit of the CoA-synthesizing protein complex (CoA-SPC)
YJL097W	PHS1	201562	PTPLB	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane
YJR006W	POL31^b	5425	POLD2	Subunit of DNA polymerase delta (polymerase III)
YKL013C	ARC19^b	10093	ARPC4^c	Subunit of the ARP2/3 complex
YKL024C	URA6^b	51727	CMPK1^c	Uridylate kinase
YKL033W	TTI1^b	9675	TTI1	Subunit of the ASTRA complex, involved in chromatin remodeling
YKL035W	UGP1^b	7360	UGP2^c	UDP-glucose pyrophosphorylase (UGPase)
YKL145W	RPT1	5701	PSMC2	ATPase of the 19S regulatory particle of the 26S proteasome
YKL189W	HYM1	51719; 81617	CAB39; CAB39L	Component of the RAM signaling network
YML069W	POB3^b	6749	SSRP1	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p)
YML077W	BET5^b	58485	TRAPPC1	Core component of transport protein particle (TRAPP) complexes I-III
YMR208W	ERG12	4598	MVK	Mevalonate kinase
YMR308C	PSE1^b	3843	IPO5	Karyopherin/importin that interacts with the nuclear pore complex
YMR314W	PRE5^b	5682	PSMA1	Alpha 6 subunit of the 20S proteasome
YOL133W	HRT1	9978	RBX1	RING-H2 domain core subunit of multiple ubiquitin ligase complexes
YOR143C	THI80	27010	TPK1	Thiamine pyrophosphokinase
YOR149C	SMP3^b	80235	PIGZ	Alpha 1,2-mannosyltransferase
YOR176W	HEM15	2235	FECH	Ferrochelatase
YOR236W	DFR1	1719	DHFR	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis
YPL117C	IDI1^b	3422	IDI1^c	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
YPR082C	DIB1^b	10907	TXNL4A^c	17-kDa component of the U4/U6aU5 tri-snRNP
YPR113W	PIS1	10423	CDIPT	Phosphatidylinositol synthase

Complementation by nonorthologous gene.

Yeast CIN gene.

Complementation identified by both screens.

Brief description obtained from Yeastmine.