Table 1. Human cDNAs that complement essential yeast deletion mutants.
Yeast systematic name | Yeast standard name | Human Entrez Gene ID | Human standard name | Yeast gene brief descriptiond |
---|---|---|---|---|
YBL020W | RFT1a | 29927 | SEC61A1 | Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
YBR002C | RER2 | 79947 | DHDDS | Cis-prenyltransferase involved in dolichol synthesis |
YBR029C | CDS1 | 8760 | CDS2 | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) |
YBR109C | CMD1b | 801; 805; 808 | CALM1; CALM2; CALM3 | Calmodulin |
YBR160W | CDC28b | 983; 1017 | CDK1; CDK2 | Cyclin-dependent kinase (CDK) catalytic subunit |
YBR252W | DUT1 | 1854 | DUT | Deoxyuridine triphosphate diphosphatase (dUTPase) |
YCR012W | PGK1b | 5230; 5232 | PGK1c; PGK2 | 3-Phosphoglycerate kinase |
YDL045C | FAD1b | 80308 | FLAD1c | Flavin adenine dinucleotide (FAD) synthetase |
YDL064W | UBC9b | 7329 | UBE2I | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
YDL120W | YFH1 | 2395 | FXN | Mitochondrial matrix iron chaperone |
YDL147W | RPN5b | 5718 | PSMD12c | Subunit of the CSN and 26S proteasome lid complexes |
YDL164C | CDC9b | 3978 | LIG1c | DNA ligase found in the nucleus and mitochondria |
YDL205C | HEM3 | 3145 | HMBS | Porphobilinogen deaminase |
YDR050C | TPI1b | 7167 | TPI1 | Triose phosphate isomerase, abundant glycolytic enzyme |
YDR086C | SSS1 | 23480 | SEC61G | Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
YDR208W | MSS4b | 8394; 8395 | PIP5K1A; PIP5K1Bc | Phosphatidylinositol-4-phosphate 5-kinase |
YDR236C | FMN1 | 55312 | RFK | Riboflavin kinase, produces riboflavin monophosphate (FMN) |
YDR404C | RPB7b | 5436 | POLR2G | RNA polymerase II subunit B16 |
YDR454C | GUK1 | 2987 | GUK1 | Guanylate kinase |
YDR510W | SMT3b | 7341 | SUMO1c | Ubiquitin-like protein of the SUMO family |
YEL026W | SNU13b | 4809 | NHP2L1 | RNA binding protein |
YEL058W | PCM1 | 5238 | PGM3 | Essential N-acetylglucosamine-phosphate mutase |
YER094C | PUP3b | 5691 | PSMB3 | Beta 3 subunit of the 20S proteasome |
YER112W | LSM4 | 25804 | LSM4 | Lsm (Like Sm) protein |
YER133W | GLC7b | 5499; 5501 | PPP1CA; PPP1CC | Type 1 serine/threonine protein phosphatase catalytic subunit |
YER136W | GDI1 | 2665 | GDI2 | GDP dissociation inhibitor |
YFL017C | GNA1b | 64841 | GNPNAT1c | Glucosamine-6-phosphate acetyltransferase |
YGL001C | ERG26 | 50814 | NSDHL | C-3 sterol dehydrogenase |
YGL030W | RPL30b | 6156 | RPL30 | Ribosomal 60S subunit protein L30 |
YGL048C | RPT6 | 5705 | PSMC5 | ATPase of the 19S regulatory particle of the 26S proteasome |
YGR024C | THG1 | 54974 | THG1L | tRNAHis guanylyltransferase |
YGR075C | PRP38 | 55119 | PRPF38B | Unique component of the U4/U6.U5 tri-snRNP particle |
YGR175C | ERG1 | 6713 | SQLE | Squalene epoxidase |
YGR185C | TYS1 | 8565 | YARS | Cytoplasmic tyrosyl-tRNA synthetase |
YGR277C | CAB4 | 80347 | COASY | Subunit of the CoA-synthesizing protein complex (CoA-SPC) |
YGR280C | PXR1 | 54984 | PINX1 | Essential protein involved in rRNA and snoRNA maturation |
YIL083C | CAB2 | 79717 | PPCS | Subunit of the CoA-synthesizing protein complex (CoA-SPC) |
YJL097W | PHS1 | 201562 | PTPLB | Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
YJR006W | POL31b | 5425 | POLD2 | Subunit of DNA polymerase delta (polymerase III) |
YKL013C | ARC19b | 10093 | ARPC4c | Subunit of the ARP2/3 complex |
YKL024C | URA6b | 51727 | CMPK1c | Uridylate kinase |
YKL033W | TTI1b | 9675 | TTI1 | Subunit of the ASTRA complex, involved in chromatin remodeling |
YKL035W | UGP1b | 7360 | UGP2c | UDP-glucose pyrophosphorylase (UGPase) |
YKL145W | RPT1 | 5701 | PSMC2 | ATPase of the 19S regulatory particle of the 26S proteasome |
YKL189W | HYM1 | 51719; 81617 | CAB39; CAB39L | Component of the RAM signaling network |
YML069W | POB3b | 6749 | SSRP1 | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
YML077W | BET5b | 58485 | TRAPPC1 | Core component of transport protein particle (TRAPP) complexes I-III |
YMR208W | ERG12 | 4598 | MVK | Mevalonate kinase |
YMR308C | PSE1b | 3843 | IPO5 | Karyopherin/importin that interacts with the nuclear pore complex |
YMR314W | PRE5b | 5682 | PSMA1 | Alpha 6 subunit of the 20S proteasome |
YOL133W | HRT1 | 9978 | RBX1 | RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
YOR143C | THI80 | 27010 | TPK1 | Thiamine pyrophosphokinase |
YOR149C | SMP3b | 80235 | PIGZ | Alpha 1,2-mannosyltransferase |
YOR176W | HEM15 | 2235 | FECH | Ferrochelatase |
YOR236W | DFR1 | 1719 | DHFR | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
YPL117C | IDI1b | 3422 | IDI1c | Isopentenyl diphosphate:dimethylallyl diphosphate isomerase |
YPR082C | DIB1b | 10907 | TXNL4Ac | 17-kDa component of the U4/U6aU5 tri-snRNP |
YPR113W | PIS1 | 10423 | CDIPT | Phosphatidylinositol synthase |
Complementation by nonorthologous gene.
Yeast CIN gene.
Complementation identified by both screens.
Brief description obtained from Yeastmine.