Figure 2.

Genome instability of subcultured wild type, pol2-M644L, rnh1Δ, rnh201Δ, rnh201Δ pol2-M644L, and rnh1Δ rnh201Δ strains. The total number of events per genome is indicated for each genotype as a black bar. For wild-type, pol2-M644L, rnh1Δ, rnh201Δ, rnh201Δ pol2-M644L, and rnh1Δ rnh201Δ strains, 10, 12, 10, 19, 17, and 22 genomes were analyzed by whole-genome microarrays, respectively. Since the wild-type strain was subcultured 10 times, and the mutant strains were subcultured 20 times (∼500 cell divisions), we doubled the number of events observed in the wild-type strain to make the comparisons among the strains valid.