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. 2015 Mar 2;5:8619. doi: 10.1038/srep08619

Figure 2. Representative Images of Peripheral Auditory Fiber Re-growth in Systemically Deafened Ears.

Figure 2

Systemic administration of K&F resulted in a complete loss of hair cells in the basal turn and patches of surviving supporting cells. The few neural fibers seen in the basilar membrane area of un-injected ears make short loops (A, B). In contrast, neurotrophin vector receiving ears have significantly more neural fibers, which also extend farther from the habenula (C, D: NT-3; E, F: BDNF). Neural fibers did not appear to re-grow in regions of surviving supporting cells (D, F). A prominent re-growth of neural fibers is seen in regions devoid of supporting cells (C, E). Green = Actin; Red = Neurofilament 200 kDa; Scale Bar = 50 μm.