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. 2015 Nov 18;5:16747. doi: 10.1038/srep16747

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(A) Schematic diagram of Orai1 showing the position of the substituted residues. There were 8 single mutants and two double mutants. (B) Averaged changes of current amplitude by pH_i 5.5 and 9.0 in the mutants in comparison with the WT Orai1/STIM1. Current amplitude at pH_i 5.5 and 9.0 was normalized to that at pH_i 7.4. Data were analyzed by ANOVA followed by t-test with Bonferroni correction.