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. 2015 Nov 18;5:16747. doi: 10.1038/srep16747

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Copyright © 2015, Macmillan Publishers Limited

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(A,B) effects of pHi 5.5 and pHi 8.4 on H155F in comparison with WT Orai1/STIM1. The original recordings of WT Orai1/STIM1 in A are from the Fig. 5A. Note that pH_i 5.5 and pH_i 8.4 produced much smaller change on H155F (B) compared with WT Orai1/STIM1 (A). (C) Averaged changes of current amplitude by pH_i 5.5 and 9.0. (D) Concentration-dependent effects of pH_i on H155F compared with WT Orai1/STIM1. Note that alkaline pH_i failed to potentiate H155F current amplitude, whereas acidic pH_i produced much smaller inhibition in comparison with WT Orai1/STIM1. E, Dose-response curves constructed using current amplitude normalized to the maximal current amplitude. The pKa was 7.46 ± 0.18 (n = 6–44) and 6.56 ± 0.63 (n = 6–11) for WT and H155F mutant.