FIG. 3.

The plasma–interstitial fluid model used in both healthy and type 1 diabetes mellitus subjects. See Eqs. 3 and 4 for the model parameterization details; q₁ and q₂ denote labeled glucose mass, whereas Q₁ and Q₂ denote the tracee glucose mass in the first (plasma) and second (interstitial fluid) compartments, respectively (in mg/kg). Of note is that to account for time-pooled microdialysate samples, interstitial fluid tracer-to-tracee model prediction is averaged over the time-pooled collection period (Δt = 5 min).