Figure 2.

DNA methylation colocalizes with protein deacetylation. Loss of lysine acetylation can mark HDAC activation (Sancho-Pelluz et al.⁴). Stainings for 5mC and lysine acetylation (Ac. lysines) were here combined, which resulted in that 5mC staining often occurred in nuclei where acetylated lysines were very low or absent, suggesting an interplay between HDAC and DNMT activities. This was seen in (a) rd1 mouse, as well as in (b) S334ter and (c) P23H rat retinae. ONL: the individual figures are oriented such that this layer is up and inner retinal layers are down. Scale bar=20 μm. The results are representative for observations made in at least three different individuals of each genotype