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. 2014 Dec 4;5(12):e1558. doi: 10.1038/cddis.2014.512

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Short-term DNMT inhibition protects rd1 photoreceptor in vitro. (a and b) Treatment with the DNMT inhibitor decitabine for 4 days in vitro significantly reduced photoreceptor cell death (expressed as the percentage of TUNEL-positive cells in the ONL). (c and d) At 2.5 μM, decitabine also reduced the numbers of 5mC-positive cells. Bars represent mean±S.D., n=2–7, and values were compared using the Student's t-test. **P<0.01, ***P<0.005; ONL: the individual figures are oriented such that this layer is up and inner retinal layers are down. Scale bar=20 μm. See Material and Methods section for culturing paradigm details