Table 1. Animal strains and species used in this study; affected genes, effects, and original references.
| Strain and species | Mutated gene | Effect | Ages used | Reference |
|---|---|---|---|---|
| C3H wild-type mouse | — | — | PN11/PN19 | 56 |
| C3H rd1 mouse | Pde6b | cGMP accumulation, rapid rod photoreceptor degeneration, onset ≤PN10, concluded ≥PN21 | PN11a | 13, 20 |
| C3H rd2 mouse | Prph2 | No outer segment formation, slow rod and cone degeneration, onset ≤PN16, concluded ≥PN180 | PN19 | 57 |
| CD(S.D.) wild-type rat | — | — | PN12/PN15 | — |
| CD(S.D.) P23H rat | Rho (P23H tg) | Rhodopsin misfolding, rod degeneration, onset ≤PN15, concluded ≥PN90 | PN15 | 58 |
| CD(S.D.) S334ter rat | Rho (S334ter tg) | Rhodopsin truncation, very rapid rod degeneration, onset ≤PN10, concluded ≥PN18 | PN12 | 59 |
a
For rd1 mice, we also used PN7, PN9, PN11, PN13, and PN15 for temporal analysis of 5mC detection