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. 2014 Dec 4;5(12):e1555. doi: 10.1038/cddis.2014.523

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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ER stress-induced caspase-8 activation occurs independently of autocrine production of TNF, Fas ligand, or TRAIL. (a–f) Ripk1^+/+ MEFs were incubated for 30 min with 10 μg/ml anti-TNF (a and b) or anti-TRAIL (e and f) blocking antibodies, or recombinant mouse Fas:Fc chimera (c and d), and then stimulated with 1 μg/ml tunicamycin (Tu) (a, c, and e), or with TNF (b), anti-Fas antibody (d), or TRAIL (f) in combination with cycloheximide (CHX). The cells were then lysed and immunoblotted as indicated