Figure 2.

Cox-2-mediated resistance is dependent on its enzymatic activity and prostaglandin synthesis. (a) Celecoxib reduces the clonogenic survival of E1A-MEF expressing mmCox-2 or hsCOX-2 following incubation with St42Rag2^−/− splenocytes at indicated effector-to-target ratios. A representative photograph (left panel), and enumeration of colonies normalized to medium control are shown (right panel). (b) Tumor growth of MC-GP cells injected subcutaneously in the flanks of C57BL/6 mice. Animals were treated once daily with Celecoxib (10 mg/kg) or solvent by gavage. Mean values (±S.E.M.) of six mice per group are shown