Figure 1.

BMPR2 expression is correlated with clinicopathological features of chondrosarcomas, and predicts treatment outcome. (a) Western blot analysis showed that BMPR2 was expressed in chondrosarcomas but not in the normal articular cartilage tissues. (b) Average expression levels of BMPR2 of normal articular cartilage and chondrosarcoma tissues. Data are presented as mean±S.D. (n=12). **P<0.001. (c) The expression of BMPR2 in a cohort of 78 human chondrosarcoma specimens was determined by IHC staining of BMPR2. Representative images of BMPR2 IHC staining in normal and chondrosarcoma specimens are shown. (d) Kaplan–Meier curves for relapse-free survival in chondrosarcoma patients with or without positive BMPR2 staining. Positive BMPR2 staining (>10% cells stained with BMPR2) in chondrosarcoma specimens is significantly associated with a poorer relapse-free survival (P=0.030)