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. 2015 Jun 1;5:10760. doi: 10.1038/srep10760

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Copyright © 2015, Macmillan Publishers Limited

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The initial step is the docking of each partner (receptor, c-Src, c-Raf, MEK1 and ERK1) on the β-arrestin. During this initial step, the solutions obtained for the β-arrestin/ERK complex were not satisfying since they were not compatible with MEK interaction. Since ERK and MEK need to interact within the complex, resulting in ERK activation, we docked ERK on the predicted β-arrestin/MEK complex. The different models were then reassembled, and it should be noted that no other docking was necessary at this step since all the heterodimer models were compatible with each other.