Table 1. Known interactions in the receptor/β-arrestin/ERK module complex. Interacting amino acids present in the models or compatible are shown in bold, those not found and not easily compatible are shown in italic.

Partner 1	Partner 2	Residues/Regions	Ref. and remarks
β-arrestin 2	receptor	L68 V70 L71 L73 V167 L191 S234 Y238 T246	23
β-arrestin 1	receptor	Finger, middle and lariat loops	21
β-arrestin 1	receptor	K77 D78	21
Receptor	β-arrestin 1/2	IL2 IL3	51,52
Receptor	β-arrestin 1/2	K265	21
β-arrestin 1	c-Src	P91 P121	12,53
c-Src	β-arrestin 1	SH3 domain	12,53
β-arrestin 1	Raf1	R307	18
β-arrestin 1 & 2	Raf1	N-domain C-domain	8
β-arrestin 1 & 2	MEK1	N-domain C-domain	8
β-arrestin 1	MEK1	D26 D29	6
MEK1	β-arrestin 1	46-70 R47, K48, R49	6
β-arrestin 2	ERK1	K295	20
β-arrestin 1 & 2	ERK1	N-domain C-domain	8
ERK1	MEK1	T202 Y204	phosphorylated by MEK1
MEK1	Raf1	270-307	29
MEK1	Raf1	S218 S222	19 phosphorylated by Raf1