Table 4.
Clinical biomarkers and sputum differential counts by cohort at Screening/Baseline Visits
| Cohorts | Healthy | Mild | Moderate | Severe | p-value*** |
|---|---|---|---|---|---|
| n (blood/sputum) | 30/20 | 52/32 | 55/38 | 51/40 | |
| FENO (ppb)* | NA | 32.9 (+64.2/-16.9) | 29.1 (+61.0/-13.9) | 28.8 (+64.7/-12.9) | NA/0.59 |
| bEOS, cells/μl* | 112 (+218/-57) | 178 (+347/-91) | 197 (+435/-89) | 210 (+452/-97) | 0.0018/0.54 |
| bNEU, 1000 cells/μl* | 3.47 (+4.96/-2.42) | 3.59 (+4.72/-2.74) | 3.64 (+4.92/-2.69) | 3.94 (+5.89/-2.63) | 0.35/0.32 |
| Serum IgE, RFU* | 1.0 (+2.1/-0.7) | 8.3 (+25.3/-6.2) | 9.8 (+26.7/-7.2) | 12.1 (+31.0/-8.7) | <0.0001/0.35 |
| Sputum eosinophils, % of WBC* | 0.38 (+0.78/-0.25) | 1.12 (+5.38/-0.93) | 3.12 (+13.62/-2.54) | 2.70 (+12.27/-2.21) | <0.0001/0.033 |
| Sputum lymphocytes, % of WBC** | 1.16 (1.05) | 1.29 (1.42) | 0.98 (1.19) | 0.94 (1.25) | 0.64/0.48 |
| Sputum macrophages, % of WBC** | 44.57 (19.42) | 50.20 (31.17) | 32.10 (21.45) | 43.04 (26.46) | 0.031/0.019 |
| Sputum neutrophils, % of WBC** | 53.57 (20.06) | 43.88 (30.90) | 56.99 (26.13) | 48.10 (25.52) | 0.19/0.13 |
*Geometric mean (asymmetric standard deviation) reported by cohort
**Mean (standard deviation) reported by cohort
***p-value (ANOVA F-test) for differences across severity cohorts, including/excluding healthy control cohort (based on log-transformed data when geometric means reported)
NA = not applicable (not measured in healthy cohort)