Table 1.
Immune-related genes putatively targeted by NeurimmiRs
| Classification | Target Gene | Gene ID | NCBI Accession Number | miRNA | miRNA Expression |
|---|---|---|---|---|---|
| Receptors | carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) | CGI_10010080 | EKC30453 | cgi-miR-242 | ACh (+1) |
| C-type mannose receptor 2 (MRC2) | CGI_10013598 | EKC36613 | scaffold987_25421 | ACh (+) | |
| Toll like receptor 1 (TLR1) | CGI_10021136 | EKC32484 | scaffold43122_31369 | ACh (+) | |
| multiple epidermal growth factor-like domains 10 (MEGF10) | CGI_10022484 | EKC30915 | scaffold987_25421 | ACh (+) | |
| CD63 antigen (CD63) | CGI_10024556 | EKC30322 | scaffold444_16949 | ACh (+) | |
| muscarinic acetylcholine receptor (mAChR) | CGI_10026715 | EKC38948 | scaffold1535_2758 | ACh (+) | |
| macrophage mannose receptor 1 (MRC1) | CGI_10003643 | EKC21607 | scaffold659_26519 | NE (+) | |
| nicotinic acetylcholine receptor (nAChR) | CGI_10012300 | EKC27791 | cgi-miR-1989 | NE (+) | |
| Signaling molecules | CREB-binding protein (CREBBP) | CGI_10004570 | EKC21118 | scaffold987_25421 | ACh (+) |
| Ras-related protein Rab-21 (RAB-21) | CGI_10012407 | EKC30126 | scaffold625_3183 | ACh (−2) | |
| E3 ubiquitin-protein ligase mib2 (MIB2) | CGI_10012437 | EKC24345 | scaffold987_25421 | ACh (+) | |
| Ras-related protein Rab-5C (RAB-5C) | CGI_10016941 | EKC27651 | scaffold987_25421 | ACh (+) | |
| TNF receptor-associated factor 3 (TRAF3) | CGI_10019401 | EKC37852 | scaffold365_16162 | ACh (+) | |
| TNF alpha-induced protein 3 (TNFAIP3) | CGI_10016154 | EKC18030 | cgi-miR-1989 | NE (+) | |
| suppressor of G2 allele of SKP1 homolog (SUGT1) | CGI_10016471 | EKC33616 | cgi-miR-184d | NE (+) | |
| Immune effector | Catalase (CAT) | CGI_10003354 | EKC25821 | scaffold987_25421 | ACh (+) |
| heat shock 70 kda (HSP70) | CGI_10006158 | - | scaffold625_3183 | ACh (−) | |
| interferon-induced protein 44 (IFI44) | CGI_10011953 | EKC23550 | scaffold1121_5128 | ACh (+) | |
| HSP70 | CGI_10014234 | - | scaffold444_16949 | ACh (+) | |
| HSP70 | CGI_10014235 | XP_011426978 | scaffold444_16949 | ACh (+) | |
| complement C1q-like protein 4 (C1qL4) | CGI_10026904 | EKC37620 | scaffold105_17058 | ACh (+) | |
| cytochrome p450 (P450) | CGI_10011491 | EKC33448 | scaffold659_26519 | NE (+) | |
| P450 | CGI_10012275 | EKC18482 | cgi-miR-184a | NE (+) | |
| HSP70 | CGI_10027276 | EKC43179 | cgi-miR-184a | NE (+) |
1miRNA increased in corresponding group
2miRNA decreased in corresponding group