. 2015 Aug 4;21(8):1145–1151. doi: 10.1038/mp.2015.108

Table 1. Evaluation of the I/D ratio across four MAF ranges (0–0.01, 0.01–0.05, 0.05–0.15 and 0.15–0.50) and two thresholds of nominal significance in the case–control analysis (P _CC <0.01 and P _CC <0.001).

MAF range	Assoc. P	No. SNPs	Obs. I/D ratio	Exp. I/D ratio	Observed log2(I/D)	Expected log2(I/D) (s.d.)	Z-score	P_I/D
0–0.01	0.01	467	3.396	6.400	1.764	2.652 (0.271)	−3.282	0.001
0–0.01	0.001	73	8.000	32.159	3.000	4.861 (0.697)	−2.668	0.008
0.01–0.05	0.01	62	2.211	1.435	1.144	0.473 (0.369)	1.819	0.069
0.01– 0.05	0.001	6	6.000	2.818	2.585	1.035 (1.222)	1.268	0.205
0.05–0.15	0.01	31	1.000	1.231	0.000	0.209 (0.510)	−0.410	0.682
0.05–0.15	0.001	2	0.500	1.703	−1.000	0.307 (1.211)	−1.079	0.280
0.15–0.50	0.01	60	0.903	1.098	−0.147	0.075 (0.416)	−0.533	0.594
0.15–0.50	0.001	6	0.667	1.552	−0.585	0.103 (1.264)	−0.544	0.586

Abbreviations: I/D, increaser/decreaser; MAF, minor allele frequency; SNP, single-nucleotide polymorphism. The expected I/D ratios were calculated using 1000 permutations of the phenotype to determine the null distribution. The chi-square P_I/D values assess the difference between the observed and expected I/D ratios.

Table 1. Evaluation of the I/D ratio across four MAF ranges (0–0.01, 0.01–0.05, 0.05–0.15 and 0.15–0.50) and two thresholds of nominal significance in the case–control analysis (P CC <0.01 and P CC <0.001).

Table 1. Evaluation of the I/D ratio across four MAF ranges (0–0.01, 0.01–0.05, 0.05–0.15 and 0.15–0.50) and two thresholds of nominal significance in the case–control analysis (P _CC <0.01 and P _CC <0.001).