Table 3.
Summary of meta-analysis of association of PCSK9 E670G polymorphism and CAD risk
| N | n (CAD/controls) | Dominant model | Allelic model | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95 % CI) | POR | I 2 (%) | PQ | OR (95 % CI) | POR | I 2 (%) | PQ | |||
| All | 9 | 1517/1795 | 1.601 (1.314–1.951) | <0.001 | 30.4 | 0.175 | 1.546 (1.301–1.838) | <0.001 | 36.3 | 0.128 |
| Ethnicity | ||||||||||
| Asians | 7 | 1215/1455 | 1.590 (1.278–1.978) | <0.001 | 44.0 | 0.098 | 1.503 (1.244–1.816) | <0.001 | 45.5 | 0.088 |
| non-Asians | 2 | 302/340 | 1.652 (1.040–2.626) | 0.034 | 0.0 | 0.386 | 1.788 (1.166–2.743) | 0.008 | 0 | 0.318 |
| HWE | ||||||||||
| P > 0.05 | 7 | 1397/1675 | 1.633 (1.321–2.018) | <0.01 | 41.7 | 0.11 | 1.627 (1.335–1.983) | <0.001 | 43.6 | 0.100 |
| P < 0.05 | 2 | 120/120 | 1.411 (0.819–2.430) | 0.215 | 0 | 0.327 | 1.306 (0.912–1.869) | 0.145 | 0 | 0.360 |
OR odds ratio, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, HWE Hardy-Weinberg equilibrium, N number of study, n number of individuals