Table 4.
Summary of meta-analysis of association of PCSK9 E670G polymorphism and lipid levels
| TC | TG | HDL-C | LDL-C | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group and subgroups | N/n | SMD (95 % CI) | P | I 2 (%) | PQ | N/n | SMD (95 % CI) | P | I 2 (%) | PQ | N/n | SMD (95 % CI) | P | I 2 (%) | PQ | N/n | SMD (95 % CI) | P | I 2 (%) | PQ |
| All | 22/13933 | 0.126 (0.023–0.229) | 0.016 | 57.4 | <0.001 | 20/6982 | 0.031 (−0.048–0.110) | 0.440 | 28.6 | 0.114 | 21/8147 | −0.123 (−0.251-0.006) | 0.061 | 63.7 | <0.001 | 23/14252 | 0.170 (0.053–0.287) | 0.004 | 68.2 | <0.001 |
| Ethnicity | ||||||||||||||||||||
| Asian | 11/3813 | 0.133 (−0.067–0.334) | 0.193 | 67.3 | <0.001 | 11/3813 | 0.075 (−0.031–0.180) | 0.164 | 12.6 | 0.325 | 11/3813 | −0.224 (−0.423–−0.025) | 0.027 | 66.5 | 0.001 | 11/3813 | 0.286 (0.021–0.551) | 0.034 | 81.4 | <0.001 |
| non-Asian | 11/10120 | 0.126 (0.014–0.238) | 0.027 | 46.5 | 0.044 | 9/3169 | −0.024 (−0.142–0.094) | 0.688 | 41.5 | 0.090 | 104234 | −0.017 (−0.165–0.132) | 0.825 | 48.5 | 0.042 | 12/10439 | 0.097 (0.011–0.184) | 0.027 | 18.8 | 0.259 |
| Type of study | ||||||||||||||||||||
| Cohort | 13/11668 | 0.133 (0.010–0.256) | 0.034 | 53.9 | 0.011 | 9/4411 | −0.097 (−0.222–0.029) | 0.132 | 14.4 | 0.31 | 10/5476 | 0.050 (−0.053–0.153) | 0.342 | 0.0 | 0.883 | 14/11987 | 0.100 (0.004–0.197) | 0.042 | 31.7 | 0.122 |
| C-C | 9/2265 | 0.119 (−0.077–0.315) | 0.235 | 65.4 | 0.003 | 11/2571 | 0.113 (0.012–0.214) | 0.028 | 7.1 | 0.376 | 11/2571 | −0.257 (−0.467–−0.048) | 0.016 | 74.3 | <0.001 | 9/2265 | 0.307 (0.027–0.588) | 0.031 | 83.3 | <0.001 |
C-C case–control, SMD standardized mean difference, CI confidence interval, P OR p values for odds ratio, P Q p values for heterogeneity form Q-test, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, N number of study, n number of individuals