Table 1.

NEPTUNE Urine Collection Timeline

Visit Numbera	V1	V2	V3	V4	V5	V6	V7	V8	V9	V10	V11	V12	V13
Eligibility assessment	X
Baseline H&P		X
Follow-up H&P				X	X	X	X	X	X	X	X	X	X
Biosample baseline		X
Biosample follow-up				X	X	X	X	X	X	X	X	X	X
24-hour urine		X		X	X	X		X		X		X	X
Clean catch/(Spot) urine		X		X	X	X	X	X	X	X	X	X	X
Renal biopsy tissue			Xb

Abbreviations: H&P history and physical examination, UA urinalysis, macroscopic (color, appearance, specific gravity, pH, leukocyte esterase, nitrite, protein, glucose, ketones, urobilin, bilirubin, blood), V visit

^aThere will be a total of 13 visits for the anticipated 600 participants in the study. In each visit, a total of 11 tubes will be generated (3 of 5 mL tubes, 7 of 2 mL tubes and 1 of 50 mL tube)

^bRenal biopsy includes a pre-biopsy 10 mL spot urine