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. 2015 Mar 13;5:9100. doi: 10.1038/srep09100

Figure 5. LPS and IL-10 employ different mechanisms in distinct myeloid cells.

Figure 5

(A) CpG percent at the promoters of AIR and not-AIR genes. Promoter is defined as −450 bp +50 bp around the TSS. The numbers of CG dinucleotides were counted within that window and divided by the number of promoters in each cell type. The grey dotted line indicates a CpG island frequency of 0.75. Mann-Whitney-U test, **p-value < 0.01. n.s. not significant. (B) Motif enrichment at the promoters of AIR and not-AIR genes. (C) Changes in expression of Irf family transcripts and Nfkb family transcripts. (D) Boxplots of changes in Irf and Nfkb family transcripts. (E) A putative model for the differing mechanisms stimulated by LPS and IL-10 in the four cell types with both a pro and anti-inflammatory response.