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Structure of the D14-GR24 complex. (A) Simulated annealing 2Fo-Fc electron density omit maps surrounding GR24 and the ligand-binding pocket, contoured at increasing σ levels. (B) The overall structure of the D14-GR24 complex in three different orientations, showing an open pocket that is surrounded by an open lid domain (yellow) consisting of double layer V-shaped helices. The pocket surface is shown as purple mesh and the modeled GR24 as van der Waals spheres.
