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. 2015 Oct 16;25(11):1219–1236. doi: 10.1038/cr.2015.122

Figure 8.

Figure 8

Structure and activity of GR24-like ligands that promote D3-D14 interaction. (A) Chemical structure of GR24, Br-PMF, I-PMF, CN-PMF, Br-BMF, ABC-ring, D-ring and karrikins (KAR1 and KAR2). All these compounds contain a conserved D-ring structure, which is required for SL function. PMF: 5-phenoxy-3-methylfuran-2(5H)-one; BMF: 3-methyl-5-(pyridin-3-yloxy)furan-2(5H)-one. (B) AlphaScreen assay showing interaction between D14 (inlet: DAD2) and D3 promoted by GR24-like ligands. The GR24-induced interaction between D14/DAD2 and D3 is normalized to 1.0 (n = 3, error bars = SD).