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. 2015 Oct 30;25(11):1250–1264. doi: 10.1038/cr.2015.126

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Copyright © 2015 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

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Analysis of HCC and noncancerous liver tissues. (A) Principal component analysis of 27 pairs of HCCs (T(HCC), red) and adjacent tissues (T(Aj), green) and 3 normal liver tissues (T(NL), blue) distinguishes most (23 of 27) HCCs from the noncancerous tissues. PC, principal component. (B) Volcano plot for differentially methylated CGIs between the HCCs and the adjacent noncancerous liver tissues. The x axis shows the fold changes of the average methylation value between the HCCs and the adjacent tissues, and the y axis shows the q-value as the FDR analogue of the P value (−Log₁₀(q-value)) for a two-tailed MWW test of differences between two groups. The dashed line indicates statistical significance (FDR < 0.05). A total of 866 CGIs (t^dmCGIs) were differentially hypermethylated in HCC tissues.