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. 2015 Sep 17;6(9):e1885. doi: 10.1038/cddis.2015.230

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Infusion of BM-MSCs regulated autophagic activity of pancreatic β cells in T2D rats. (a) LAMP2 expression in β cells was assessed by immunofluorescence analysis. Scale bar, 100 μm. (b) β-Cell apoptosis was detected using TUNEL assay by immunofluorescence analysis according to the presence of insulin- (red) and TUNEL-positive (green) cells. Scale bar, 50 μm. (c and d) TEM analysis showed ultrastructural changes in pancreatic β cells. Blue arrows, autophagosomes; yellow arrows, autolysosomes; red arrows, insulin granules. Scale bar, 2 μm (c), 0.5 μm (d). Magnification: × 15 000 (c), × 40 000 (d). n=10 rats per group