Figure 3.

TUDCA inhibited the LPS-induced IRE1α and PERK hepatic activities by favoring anti-apoptotic signaling pathways in ob/ob mice. The expression of ER stress (a and b) and apoptotic proteins, presented as Bcl-2 family pro-apoptotic/anti-apoptotic ratios (c and d), was compared by immunoblotting and quantified (n=6–9). Data are expressed as mean±standard error of the mean. Statistical significance from controls is denoted by *^,#P≤0.05, **^,##P≤0.01, ***^,###P≤0.001