Table 2.
Demographics, clinical staging, treatments, PLK1 mRNA and FOXM1 mRNA expression of the patients in each tissue group
| Gastric normal | Gastric adenocarcinoma | |
|---|---|---|
| Number of cases | 13 | 8 (1HGD) |
| Male | 4 (31) | 7 (88) (p = 0.02) |
| Age | 72 ± 3 | 70 ± 4 (p = 0.45) |
| Smoking | ||
| Never | 1 (8) | 1 (11) (p = 0.45) |
| Ex-smoker | 1 (8) | 2 (22) (p = 0.98) |
| Current | 5 (38) | 6 (67) (p = 0.09) |
| Missing | 6 (46) | 0 |
| Pathological differentiation | ||
| Poor | 6 (75) | |
| Moderate | 0 | |
| Well | 0 | |
| Missing | 2 (25) | |
| Depth of invasion | ||
| T1 | 1 (13) | |
| T2 | 2 (25) | |
| T3 | 3 (50) | |
| T4 | 0 | |
| Missing | 1 (13) | |
| Metastatic disease | ||
| Local (N) | 3 (37.5) | |
| Distant (M) | 0 (0) | |
| AJCC 2010 Stage | ||
| 1 | 2 (25) | |
| 2 | 3 (36) | |
| 3 | 2 (25) | |
| 4 | 0 | |
| Missing | 1 (13) | |
| Treatment | ||
| Surgery | 6 (75) | |
| Surgery and chemotherapy | 1 (13) | |
| Chemotherapy | 0 | |
| Chemo-radiotherapy | 0 | |
| EMR | 0 | |
| Palliative care | 1 (13) | |
| Missing | 0 | |
| PLK1 mRNA expression | ||
| mRNA level ×10 | 2.1 | 18.8 |
| Positive expression | 2 (15) | 5 (63) (p = 0.056) |
| FOXM1 mRNA expression | ||
| mRNA level ×10 | 1.2 | 9.2 |
| Positive expression | 0 (0) | 6 (75) (p = 0.001) |
The number of cases is shown in each category, percentages are in brackets. mRNA levels are mean expression levels and standard deviation relative to 18S ribosomal RNA and standards derived from HET1a cell lines. The number of patients with clinical data missing is indicated. Positive expression is defined as an expression level equal or higher to the mean of the normal sample plus two standard deviations about the mean for the indicated gene. P values calculated by Chi2 test are indicated
HGD high grade dysplasia, EMR endoscopic mucosal resection