Table 2. Clinical sign scores of three groups over the periods.

Time period	Clinical sign score	Group I	Group II	Group III	χ2 value	p value
baseline/0 mon	1	25 (100.0)	25 (100.0)	25 (100.0)	NA	-
	2	0 (0.0)	0 (0.0)	0 (0.0)
	3	0 (0.0)	0 (0.0)	0 (0.0)
	4	0 (0.0)	0 (0.0)	0 (0.0)
3 mon	1	25 (100.0)	25 (100.0)	24 (96.0)	2.03	0.363
	2	0 (0.0)	0 (0.0)	1 (4.0)
	3	0 (0.0)	0 (0.0)	0 (0.0)
	4	0 (0.0)	0 (0.0)	0 (0.0)
6 mon	1	25 (100.0)	25 (100.0)	20 (80.0)	10.71	0.030
	2	0 (0.0)	0 (0.0)	4 (16.0)
	3	0 (0.0)	0 (0.0)	1 (4.0)
	4	0 (0.0)	0 (0.0)	0 (0.0)
9 mon	1	25 (100.0)	25 (100.0)	20 (80.0)	10.71	0.030
	2	0 (0.0)	0 (0.0)	1 (4.0)
	3	0 (0.0)	0 (0.0)	0 (0.0)
	4	0 (0.0)	0 (0.0)	4 (16.0)

The numbers in the parentheses were the percentages of the cases rated as the score.

NA, not applicable.