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. 2015 Apr 23;6(4):e1730. doi: 10.1038/cddis.2015.66

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Donor p65^+/− MDSC engraftments promote the repair of recipient muscle. (a) Immunofluorescent staining of tissue for the macrophage marker CD68 (green) indicated that RFP+ donor cell (red) engraftments in injured muscle were infiltrated by macrophages within 24 h postinjection (48 h postinjury), which continued to persist at 7 days (bottom). (b) eMyHC+ fibers (green) could be identified in or around donor cell engraftments at 7 days. (c) Quantification of CD68 positivity within x20 images indicated that p65^+/− MDSC engraftments have significantly less CD68+ cells present at 7 days (*P⩽0.05), and (d) demonstrated a trend towards higher numbers of total eMyHC+ fibers (host+donor) (P=0.12). Data are displayed as mean±S.E.M.; n=3–4 mice per group. Scale bar: 100 μm