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. 2015 Apr 9;6(4):e1713. doi: 10.1038/cddis.2015.85

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Wg signaling promotes caspase-independent cell death. Light micrographs of Drosophila adult eyes (a–f) and fluorescent micrographs of third instar eye discs (g–x) are shown. Compared with the GMR-Gal4 control (a, g, m, s), expression of Hep^CA, Wg, Dsh, or Arm induces reduced-eye size phenotypes (b–e), increased cell death by AO (h–k) and TUNEL staining (n–q), but no caspase activation indicated by cleaved caspase-3(Cas3*) antibody staining (t–w). Expression of Rpr serves as a positive control which induces caspase-dependent cell death (f, l, r, x)