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. 2015 Apr 16;6(4):e1720. doi: 10.1038/cddis.2015.93

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of spermidine on optic nerve regeneration following ONI in vivo. (a) Longitudinal sections through the optic nerve showing CTB-positive axons distal to the injury site (*) in control and spermidine-treated mice at d14 after ONI. Arrowheads indicate regenerating axons. Scale bar: 100 μm. (b) Higher magnification of the images shown in a. Scale bar, 50 μm. (c) Quantitative analyses of regenerating axons extending 250 and 500 μm from the injury site at d14 after ONI. The data are presented as means±S.E.M. of six samples for each experiment. **P<0.01