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. 2014 Nov 21;25(1):50–66. doi: 10.1038/cr.2014.150

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Copyright © 2015 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0

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Cartoon model of allosteric AMPK regulation. (A) Regulation by adenine nucleotides. (B) Regulation by glycogen and compound 991. The α-subunit of AMPK is shown in green, with the AID-αRIM module in light green, the β-subunit in brown, and the γ-subunit in yellow. Arrows indicate the directions of allosteric modulator-induced movements within the AMPK complex, as referred to in the text by the numbers in circles next to the arrows. P, CBM phosphorylation; G, glycogen; 9, compound 991. See text for details.