Table 3. Multiple logistic regression models for diabetes in relation to betatrophin.
T1, n = 537 T2D n = 45 Non-diabetic n = 492 | T2, n = 532 T2D n = 149 Non-diabetic n = 383 | T3, n = 534 T2D n = 362 Non-diabetic n = 140 | P-trend | |
---|---|---|---|---|
Betatrophin§ (pg/mL) | 500.0 (59.5 – 700.0) | 932.4 (701.4 – 1287.5) | 2078.9 (1289.5 – 12361.1) | <0.0001 |
Models | ||||
T2D | Reference | OR (95% CI) | OR (95% CI) | |
Model 1 | 1 | 2.82 (1.92 – 4.14) | 10.94 (7.29 – 16.42) | <0.0001 |
Model 2 | 1 | 2.66 (1.80 – 3.92) | 10.09 (6.68 – 15.24) | <0.0001 |
Model 3 | 1 | 1.52 (0.82 – 2.79) | 7.37 (3.87 – 14.04) | <0.0001 |
Model 4 | 1 | 1.46 (0.78 – 2.73) | 6.15 (3.15 – 12.01) | <0.0001 |
Model 1 adjusted for age, gender, and ethnicity; Model 2 adjusted for BMI, waist/hip ratio + Model 1; Model 3 adjusted for HbA1c, HOMA-IR, and HOMA-β + Model 2. Model 4 adjusted for total cholesterol, triglyceride, LDL, HDL, systolic, diastolic blood pressure + Model 3. Tertile values of betatrophin are expressed as T1 (<700.0), T2 (700.0 – 1287.5), and T3 (>1287.5).
§Betatrophin presented as Median (range).