Table 3. Multiple logistic regression models for diabetes in relation to betatrophin.

	T1, n = 537 T2D n = 45 Non-diabetic n = 492	T2, n = 532 T2D n = 149 Non-diabetic n = 383	T3, n = 534 T2D n = 362 Non-diabetic n = 140	P-trend
Betatrophin§ (pg/mL)	500.0 (59.5 – 700.0)	932.4 (701.4 – 1287.5)	2078.9 (1289.5 – 12361.1)	<0.0001
Models
T2D	Reference	OR (95% CI)	OR (95% CI)
Model 1	1	2.82 (1.92 – 4.14)	10.94 (7.29 – 16.42)	<0.0001
Model 2	1	2.66 (1.80 – 3.92)	10.09 (6.68 – 15.24)	<0.0001
Model 3	1	1.52 (0.82 – 2.79)	7.37 (3.87 – 14.04)	<0.0001
Model 4	1	1.46 (0.78 – 2.73)	6.15 (3.15 – 12.01)	<0.0001

Model 1 adjusted for age, gender, and ethnicity; Model 2 adjusted for BMI, waist/hip ratio + Model 1; Model 3 adjusted for HbA1c, HOMA-IR, and HOMA-β + Model 2. Model 4 adjusted for total cholesterol, triglyceride, LDL, HDL, systolic, diastolic blood pressure + Model 3. Tertile values of betatrophin are expressed as T1 (<700.0), T2 (700.0 – 1287.5), and T3 (>1287.5).

^§Betatrophin presented as Median (range).