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. 2015 Jun 19;5:11471. doi: 10.1038/srep11471

Figure 4. Representative immunohistochemical staining of MAP3K3 protein in lung tissues and correlation with patient survival.

Figure 4

Immunostaining of MAP3K3 in normal lung tissue (A) and (B), lung ADC tissues (C)–(F), and tumor-infiltrating lymphocytes (G) and (H). Original magnifications: (A), (B) and (H) x40, others are x20. (I): MAP3K3 positive tumor staining (score 2 and 3) is favorable for patient survival as compared to negative or weak staining (score 0 and 1) as determined by log-rank test. (J): MAP3K3 positive tumor-infiltrating lymphocyte staining (score 2 and 3) is favorable for patient survival as compared to negative or weak staining. (K): Both ADC (T) and lymphocyte (L) positive staining ADCs (#3 inside the figure) have better survival as compared to other groups in generally (p = 0.06), and p = 0.01 when both stained positive (#3 inside the figure, n = 30/88, 34.1%) versus both negative (#0 inside the figure, n = 30/88, 34.1%). Patient survival with staining T positive and L negative (#1 inside the figure, n = 12/88, 13.6%) or T negative and L positive (#2 inside the figure, n = 16/88, 18.2%) is in the middle.