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. 2015 May 27;5:10622. doi: 10.1038/srep10622

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Success rates. We measured the ratio of successful agents in the population, for different mesenchymals/amoeboids ratios and different energy intake rates q = 0.5, 0.6, 0.8, 1.0 from bottom to top. (a)-(b) With no interaction: the presence of more mesenchymals is beneficial only when the energy is sufficient for effective wall degradation. (a) The success rate of mesenchymal agents; (b) The success rate of amoeboid agents. (c)-(d) With constant cell-cell alignment interaction as described in eqs. (7)-(8), , with parameter values as indicated in Supporting Table T1. (c) The success rate of mesenchymal agents. Interaction improves the success of mesenchymals dramatically for the lower energy levels, but slightly impairs the success rate for high energy. (d) The success rate of amoeboid agents. Interaction impairs the success of amoeboids, in all energy states and low mesenchymal population. Interestingly, with interaction and high mesenchymal ratio, the success rate of amoeboids increases due to the efficient path generation.