Table 1. Correlations between LKB1 expression and clinicopathologic features in patients with pancreatic ductal adenocarcinoma (PDAC).
| Expression of LKB1 | ||||
| Clinicopathological feature | Total 205 | Low (n = 36, 17.6%) | High (n = 169, 82.4%) | P value (χ2 test) |
| Age (years) | ||||
| ≤65 | 107 | 17 (15.9) | 90 (84.1) | 0.511 |
| >65 | 98 | 19 (19.4) | 79 (80.6) | |
| Gender | ||||
| Male | 117 | 16 (13.7) | 101 (86.3) | 0.092 |
| Female | 88 | 20 (22.7) | 68 (77.3) | |
| Clinical stage (AJCC) | ||||
| I | 23 | 1 (4.3) | 22 (95.7) | 0.001 |
| II | 135 | 19 (14.1) | 116 (85.9) | |
| III | 34 | 14 (41.2) | 20 (58.8) | |
| IV | 13 | 2 (15.4) | 11 (84.6) | |
| Size | ||||
| ≤2 cm | 41 | 3 (7.3) | 38 (92.7) | 0.054 |
| >2 cm | 164 | 33 (20.1) | 131 (79.9) | |
| T classification | ||||
| T1 | 7 | 0 (0.0) | 7 (100.0) | 0.025 |
| T2 | 31 | 1 (3.2) | 30 (96.8) | |
| T3 | 129 | 24 (18.6) | 105 (81.4) | |
| T4 | 38 | 11 (28.9) | 27 (71.1) | |
| N classification | ||||
| Absent | 143 | 19 (13.3) | 124 (86.7) | 0.015 |
| Present | 62 | 17 (27.4) | 45 (72.6) | |
| Liver metastasis | ||||
| Absent | 192 | 30 (15.6) | 162 (84.4) | 0.005 |
| Present | 13 | 6 (46.2) | 7 (53.8) | |
| Vascular invasion | ||||
| Absent | 178 | 26 (14.6) | 152 (85.4) | 0.004 |
| Present | 27 | 10 (37.0) | 17 (63.0) | |
| Tumor location | ||||
| Head | 139 | 23 (16.5) | 116 (83.5) | 0.580 |
| Body/tail | 66 | 13 (19.7) | 53 (80.3) | |
| Histological differentiation | ||||
| Well | 14 | 4 (28.6) | 10 (71.4) | 0.262 |
| Moderate/poor | 191 | 32 (16.8) | 159 (83.2) | |
Values in parentheses indicate percentage values. The bold number represents the P-values with significant differences.