Table 2. Univariate and multivariate analyses of prognostic parameters for survival in patients with pancreatic ductal adenocarcinoma (PDAC).
| Prognostic parameter | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Expression of LKB1 (low vs. high) | 0.439 | 0.288-0.669 | 0.000 | 0.542 | 0.349-0.841 | 0.006 |
| Age (≤65 vs. >65) | 1.306 | 0.953-1.788 | 0.097 | - | - | - |
| Gender (male vs. female) | 0.908 | 0.660-1.249 | 0.553 | - | - | - |
| Clinical stage (I vs. II vs. III vs. IV) | 1.560 | 1.243-1.959 | 0.000 | 1.295 | 0.999-1.678 | 0.051 |
| Size (≤2 cm vs. >2 cm) | 1.850 | 1.219-2.806 | 0.004 | 1.628 | 1.063-4.494 | 0.025 |
| T classification (T1 vs. T2 vs. T3 vs. T4) | 1.449 | 1.143-1.836 | 0.002 | 1.163 | 0.896-1.511 | 0.257 |
| N classification (absent vs. present) | 1.592 | 1.132-2.239 | 0.008 | 1.327 | 0.928-1.898 | 0.122 |
| Liver metastasis (absent vs. present) | 3.700 | 1.953-7.007 | 0.000 | 2.318 | 1.157-4.646 | 0.018 |
| Vascular invasion (absent vs. present) | 1.491 | 0.951-2.338 | 0.082 | - | - | - |
| Tumor location (head vs. body/tail) | 1.042 | 0.743-1.459 | 0.813 | - | - | - |
| Histology (well vs. moderate/poor) | 1.503 | 0.766-2.950 | 0.236 | - | - | - |
HR: Hazard ratio; CI: Confidence interval. The bold number represents the P-values with significant differences.