Skip to main content

View full-text article in PMC

. 2015 Jul 9;6(7):e1810. doi: 10.1038/cddis.2015.168

Table 1. Comparison of A-1210477 and related analogs with previous small-molecule inhibitors of prosurvival BCL-2 family proteins acting as authentic BH3 mimetics.

Compounds	Specific targets	Status
ABT-737⁵	BCL-2, BCL-XL and BCL-W	Preclinical
Navitoclax⁶	BCL-2, BCL-XL and BCL-W	Phase II trials⁷
ABT-199⁸	BCL-2	Phase III trials⁷
BM-1197⁹	BCL-2 and BCL-XL	Preclinical
A-1155463¹⁰	BCL-XL	Preclinical
A-1210477 and analogs^{1, 16}	MCL-1	Preclinical