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. 2015 Jul 23;6(7):e1833. doi: 10.1038/cddis.2015.196

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CA decreases miR-34a expression and activates the SIRT1/p66shc pathway in rat liver and L02 cells. (a) qRT-PCR analysis of miR-34a expression in the liver (left panel) and L02 cells (right panel). (b) SIRT1 protein expression in the liver (left panel) and L02 cells (right panel). (c) p66shc protein expression in the liver (left panel) and L02 cells (right panel). L02 cells were treated with CA, cholic acid or nothing. The data are presented as the mean±S.D. (n=3). *P<0.05 versus the ND group, **P<0.01 versus the ND group, ^#P<0.05 versus the HFD group, ^##P<0.01 versus the HFD group