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. 2015 Jul 23;6(7):e1833. doi: 10.1038/cddis.2015.196

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CA exerts an antiapoptotic effect through the miR-34a/SIRT1/p66shc pathway in L02 cells. L02 cells were treated with or without PA and then transfected with antago-miR-34a for 24 h or incubated with 10 μM CA for 12 h. (a) TUNEL assay ( × 200), (b) Caspase-3 and caspase-9 activity, (c) miR-34a expression and (d) SIRT1 and p66shc protein expression. The data are presented as the mean±S.D. (n=3). *P<0.05 versus the ND group, **P<0.01 versus the control group, ^##P<0.01 versus the PA group, ^&&P<0.01 versus the PA+antago-miR control group