Table 1. Amyloid-like features of aggregated PrPs.
Sequence | TEM | CR | hFTAA | ThT kinetics |
---|---|---|---|---|
BoPrP | - | + | + | + |
HuPrP | + | + | + | + |
FePrP | + | + | + | + |
MoPrP | + | + | + | + |
PoPrP | + | + | + | + |
HaPrP | + | + | + | + |
CaPrP | + | + | + | + |
TEM: Fibrillar structure detected by transmission electron microscopy (Fig. 1)
CR: Displays red green birefringence when stained with Congo red (Fig. 2a)
hFTAA: hFTAA positive aggregates displaying amyloid spectrum when monitored by fluorescence microscope (Fig. 2b)
ThT kinetics: Sigmoidal kinetic profile of ThT fluorescence (Fig. 4b)