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. 2015 Nov 6;7:ecurrents.hd.b966ec2eca8e2d89d2bb4d020be4351e. [Version 1] doi: 10.1371/currents.hd.b966ec2eca8e2d89d2bb4d020be4351e

TRX1 expression decreases striatal neuronal atrophy in HD mice.

Fig6rb

A-B. Experimental design was as described for figure 5. A. Representative images of fluorescent Nissl stained neurons in the region of the striatal injection site. Numbers below images represent the number of mice per treatment group; numbers in parenthesis represent the minimum and maximum number of neurons counted per mouse within the group. B. Striatal neuronal cell body volume. Mice expressing N171-82Q and mutant (inactive) TRX1 (mTRX1) have significantly smaller neuronal cell bodies than mice expressing N171-82Q and active TRX1. The main effect p-value is 0.0545; pair-wise comparison p-values are on graph. n=5-7, C. Spontaneous wheel running activity is not altered by N171-18/82Q and / or TXN1 expression. See methods for experimental details. n=7-9.