Fig. 5.
Regions of granuloma predicted to harbor bacterial populations at risk of developing drug resistance during treatment with RIF, and bacterial loads in these high-risk regions. a Snapshot of in silico granuloma at 100 d.p.i, prior to treatment. b Outlines of granuloma (gray) and caseum (purple) for the granuloma in (a). c-e Regions with RIF exposure (C max /C 50) in the high-risk range (0.009 to 0.07) are shown in blue for intracellular, non-replicating, and replicating extracellular bacteria. Bacteria in each subpopulation are shown in yellow. f, g Number of bacteria in high-risk regions after two weeks and 6 months of treatment for all granulomas (N = 417). h, i Total number of Mtb per granuloma, separated based on sterilization. Panels in (f-i) show mean +/− SEM