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. 2015 Nov 17;16:27. doi: 10.1186/s12860-015-0073-5

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© Ponti et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Actinomycin D induces EGR1 and B23. Relative mRNA levels of EGR1, B23, 47S,45S pre-rRNA and p300 (the last two are known gene targets of EGR1) expressed in HeLa cells treated with Actinomycin D for 1 h at 37 ° C (Panel a to d). The smaller inserts in the panels compare the effect of siRNA EGR1 plus Actinomycin D to that of Actinomycin D alone. Quantitative evaluation of EGR1 and B23 proteins under the effect of Actinomycin D, together with a representative immunoblot, are shown in Panel e to g. Data are the mean +/− s.e. of three independent experiments. Comparisons were performed by one way ANOVA. Significant results are highlighted with asterisks (*p < 0.05; **p < 0.01; ***p < 0.001)