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. 2015 Oct 30;112(44):741–747. doi: 10.3238/arztebl.2015.0741

Table 1. Comparison of non-freezing cold injury (NFCI) and frostbite.

Non-freezing cold injury Frostbite
Caused by slow temperature decrease in affected tissue with hypothermia, no direct frostbite Formation of ice crystals in tissue
Alternating phases of vasoconstriction and vasodilation in protracted hypothermia Tissue damage is immediate
Incomplete damage of tissue, nerve fibers react at early stage Direct damage of entire tissue by formation of ice crystals
Four clinical phases (Table 4) Course often very protracted, complete recovery rare
Blister formation rare Blister formation in stages II and III
Slow rewarming Rewarming in warm water (37 to 39 °C) for 15 to 60 min
Slight loading of the affected area possible, no bandaging necessary Sterile und protective bandages, topical antiseptics as required, splinting of affected extremities