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. 2015 Nov 14;34:140. doi: 10.1186/s13046-015-0255-1

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© Mileo et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — RB family proteins and mRNA modulation in HuH-7 parental and HuH-7-CORE cell lines. a and b Western blot analysis of pRb, pRb2/p130 and p107 proteins in parental HuH-7 and in core expressing HuH-7-CORE cell lines, showing a marked down-modulation of pRb and the phosphorylated form of pRb2/p130 in the HuH-7-CORE cell line. c Quantitative PCR determination of mRNA levels relative to the three RB family gene products, as indicated, in the parental HuH-7 cell line (grey bars, which refer to a 100 % relative amount) and in the HuH-7-CORE cells (black bars) constitutively expressing HCV core protein. Statistical significance: *P = <0.05; **P = <0.01