Table 1. RKIP-associated miRNAs in cancer.
miRNA | Targets | Regulation |
---|---|---|
miR-27a | RKIP, CDC27, sFRP1 | Chemoresistance, tumor growth. |
miR-224 | RKIP, ERG-2, p21 | Tumor growth, chemoresistance. |
let-7 | Ras, Myc, BACH1, HMGA1, STAT3 | Lin28 inhibits let-7, whereas RKIP inhibits let-7. Inhibition of invasion and metastasis. |
miR-200 | ZEB1, ZEB2, LOX, HMGA2, EGFR | RKIP enhances miR-200 expression. Inhibition of metastasis. |
miR-98 | ALK4, MMP11, E2F5 | miR-98 is positively correlated with RKIP. Inhibition of invasion. |