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. 2015 Nov 14;12:40. doi: 10.1186/s12986-015-0032-3

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© Glastras et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — FXR was downregulated in the kidneys of offspring of obese mothers at postnatal Days 1 and 20. mRNA expression of FXR (a) and its downstream target SREBP-1c (b) at postnatal Days 1 and 20 (b). IHC staining (c and e) and quantification (d and f) of FXR and SREBP1c at Day 20. Images shown at 400x magnification. N = 5–7 per group, *p < 0.05 and **P < 0.01