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. 2015 Jul 1;29(10):4285–4298. doi: 10.1096/fj.15-272526

Figure 2.

Figure 2.

Involvement of the SNS in TRPV1 antagonist-induced hyperthermia. NA concentrations measured in brain (A), BAT (B), and skin (C) samples of WT mice 1 h posttreatment with AMG9810 (50 mg/kg, i.p.) or vehicle (2% DMSO, 5% Tween 80 in saline) (n = 5). D) Immunoblot of UCP1 and loading control, VDAC, in BAT mitochondrial-extracted protein of AMG9810- or vehicle (Veh)-treated mice (1 h). E) Densitometric analysis of the relative expression of UCP1/VDAC (n = 3–4). F) Immunoblot of UCP3 and loading control, VDAC, in skeletal muscle (GM) mitochondrial-extracted protein of AMG9810- or vehicle-treated mice (1 h). G) Densitometric analysis of the relative expression of UCP3/VDAC (n = 4). Results are means ± sem. *P < 0.05 and **P < 0.01 vs. vehicle control using 2-tailed Student’s t test.